NFL Week 5 odds, picks, best bets Sunday

Seattle had its three-game winning streak snapped by Detroit last week in a hard-fought road game between two of the better teams in the NFC. 

The Seahawks continued to look strong on offense, accumulating 516 total yards. However, due to a laundry list of inactive players, the defense struggled, surrendering 42 points on six touchdowns to five different players.

Meanwhile, the underdog Giants hit the road without one of their top offensive producers and another is doubtful.

Here is our preview of Sunday’s Giants vs. Seahawks matchup (4:25 p.m. ET, CBS) with betting odds, a prediction and a pick.

Giants vs. Seahawks odds

Giants vs. Seahawks prediction

Seattle’s Lumen Field is one of the toughest venues and environments for road teams to win at, so the Giants have their work cut out as they also deal with crossing three time zones for this game.

They’re also facing a team with the highest-graded rushing offense, per Pro Football Focus. That’s a bad matchup for the Giants, who are ranked 20th in run defense grade and are allowing the ninth-most yards per rush attempt in the NFL.

The G-Men’s saving grace is its red-zone defense, which has allowed opponents to score touchdowns in only 25% of their trips over the past three weeks (second in NFL). 

However, Seattle has been surgical, particularly at home, in red-zone scoring, punching it in 67% of the time (No. 7 in NFL). Last week against Detroit, the Seahawks scored on three of their four trips inside the red zone (INT), with another touchdown coming on a run by Kenneth Walker just outside the Lions’ 20.

Making matters worse for the Giants, the Seahawks are expected to get several key defensive players back that were missing from last week’s loss. 

LB Jerome Baker, DL Leonard Williams, OLBs Boye Mafe and Uchenna Nwosu and first-rounder DT Byron Murphy II all missed Seattle’s “Monday Night Football” matchup against Detroit.

Baker, Williams and Nwosu have a good chance to return this week, giving Seattle a better shot at stuffing the Giants’ run game, which was exposed against Dallas in Week 4.

Devin Singletary picked up just 24 yards on 14 carries (1.7-yard average).

It could be a struggle for the Giants to pick up any meaningful yards on the ground or through the air.

The Seahawks rank first in QB pressures, which means Daniel Jones could find himself on the run throughout the game.

Historically, Jones has been poor at throwing under pressure and currently boasts the 24th-best quarterback rating and the 25th-best completion percentage in the league, which had been boosted by rookie wide receiver Malik Nabers’ incredible play through the first four games.

However, Nabers (concussion protocol) has been ruled out for Sunday’s matchup, a massive blow to an already struggling offense.

Singletary, who is dealing with a groin issue, is doubtful to play.

Betting on the NFL?

Giants vs. Seahawks pick

Without Nabers and potentially Singletary against a Seahawks defense that is getting back to health, the Giants will likely have problems moving the ball on offense.

This one could be a blowout for the home team.

Pick: Seahawks -6.5 (-120, bet365)

Why Trust New York Post Betting

Andrew Norton handicaps the NBA, WNBA, NFL, college basketball and football, UFC and golf. During the 2022-23 NBA season, he achieved a standout 14.1% ROI, cashing 60% of his NBA spread picks and leading Tallysight in its SportsIQ metric.