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The 49ers return home on Sunday with a chance to start 3-0 after dismantling their first two opponents by a combined 42 points.
San Francisco is laying 8.5 points despite their mounting injuries at receiver, a reflection of an offense that has scored touchdowns on nine of its first 12 possessions this season.
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What our Post expert thinks about Cardinals vs. 49ers
Brock Purdy was nearly flawless against Miami, completing 20-of-22 passes for 287 yards with three total touchdowns and a 149.1 passer rating.
Arizona presents an interesting divisional wrinkle, though, as Kyle Shanahan is only 9-9 against the Cardinals during his tenure despite San Francisco’s broader success.
The Cardinals will need considerably more from Jacoby Brissett and the passing game after producing just 95 yards through the air against Seattle, especially against a 49ers team capable of putting a game out of reach early on.
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Why Trust New York Post Betting
Sean Treppedi handicaps the NFL, NHL, MLB and college football for the New York Post. He primarily focuses on picks that reflect market value while tracking trends to mitigate risk.
